Short-term effect of percutaneous recanalization of chronic total occlusions on QT dispersion and heart rate variability parameters
نویسندگان
چکیده
BACKGROUND QT dispersion (QTd), which is a measure of inhomogeneity of myocardial repolarization, increases following impaired myocardial perfusion. Its prolongation may provide a suitable substrate for life-threatening ventricular arrhythmias. We investigated the changes in QTd and heart rate variability (HRV) parameters after successful coronary artery revascularization in a patient with chronic total occlusions (CTO). MATERIAL/METHODS This study included 139 successfully revascularized CTO patients (118 men, 21 women, mean age 58.3±9.6 years). QTd was measured from a 12-lead electrocardiogram and was defined as the difference between maximum and minimum QT interval. HRV analyses of all subjects were obtained. Frequency domain (LF: HF) and time domain (SDNN, pNN50, and rMSSD) parameters were analyzed. QT intervals were also corrected for heart rate using Bazett's formula, and the corrected QT interval dispersion (QTcd) was then calculated. All measurements were made before and after percutaneous coronary intervention (PCI). RESULTS Both QTd and QTcd showed significant improvement following successful revascularization of CTO (55.83±14.79 to 38.87±11.69; p<0.001 and 61.02±16.28 to 42.92±13.41; p<0.001). The revascularization of LAD (n=38), Cx (n=28) and RCA (n=73) resulted in decrease in HRV indices, including SDDN, rMSSD, and pNN50, but none of the variables reached statistical significance. CONCLUSIONS Successful revascularization of CTO may result in improvement in regional heterogeneity of myocardial repolarization, evidenced as decreased QTcd after the PCI. The revascularization in CTO lesions does not seem to have a significant impact on HRV.
منابع مشابه
Effect of Exercise Training on Heart Rate Variability in Patients with Heart Failure After Percutaneous Coronary Intervention
Background: This study aims to evaluate the effect of exercise training on heart rate variability (HRV) and to determine the correlation between parameters of HRV and the ejection fraction in patients with heart failure after percutaneous coronary intervention.Material and Methods: Fifty patients with left ventricular ejection fraction ≤ 40% undergone percutaneous coronary intervention were r...
متن کاملThe Acute Effect of Passive Smoking on QT Dispersion in 95 Healthy Men
Background: Passive cigarette smoking is a known cause of a variety of diseases. However, most of the studies done in this field have focused on its chronic effects on human health. Studies considering the acute effect of smoking on QT dispersion, on the other hand, with its known predictive role in the occurrence ventricular arrhythmia and sudden cardiac death are sparse. Objectives: This st...
متن کاملLong-term MACCE Rate after Retrograde Compared to Antegrade Recanalization of Chronic Total Coronary Occlusions
Background: The recanalization success rate of chronic total occlusion (CTO) percutaneous coronary interventions (PCI) can be increased by the retrograde approach. However, the long-term outcome of patients undergoing retrograde procedures is unknown. Aim: We aimed to evaluate the long-term MACCE (major adverse cardiac and cerebrovascular event) rate (death, myocardial infarction, coronary arte...
متن کاملA Prospective Study on QT Dispersion in Neonates: A New Risk Factor
Background: QT dispersion (QTd) especially after ischemic heart disease and myocardial infarction is a prognostic predictor of mortality, in adult medicine. Objective: This study was undertaken to determine the correlation between QT dispersion and neonatal stress. Neonates were divided into 3 groups: normal term (30 cases), normal preterm (30 cases) and sick neonates (36 cases), born between ...
متن کاملQT Dispersion: Does It Change after Percutaneous Coronary Intervention?
BACKGROUND Myocardial ischemia is one of several causes of prolonged QT dispersion. The aim of this study was to evaluate the effect that percutaneous coronary intervention has on the depolarization and repolarization parameters of surface electrocardiography in patients with chronic stable angina. METHODS We assessed the effects of full revascularization in patients with chronic stable angin...
متن کامل